![]() ![]() At 0 deg knee flexion, medial and lateral compartment articular cartilage contact area averaged 447 mm 2 and 265 mm 2, respectively. Images like this confocal reflectance micrograph of healthy articular cartilage are used to track matrix deformation and determine how loading impacts matrix structure. A mean external load of 62 N was applied in these studies. Thus early detection and assessment for knee cartilage defects are important for protecting patients from knee OA. of this process can be opened in FEBios Postview for visualization (Figure. We hypothesize that osteoarthritic tissue will exhibit a reduced sensitivity to dynamic load-induced improvements in properties and an enhanced sensitivity to degradative changes associated with stress deprivation and static loading. Cartilage defects are regarded as major manifestations of knee OA, which are visible by magnetic resonance imaging (MRI). contact stresses in the cartilage, by hampering the meniscuss ability to. Improving visualization of the articular cartilage of the knee with magnetic resonance imaging under axial traction: a comparative study of different traction weights Traction MRI examination may be useful in evaluating articular cartilage lesions at the medial tibiofemoral joint. Meanwhile, changes in microscopic mechanical and structural parameters are monitored optically and cell biosynthetic activity is assessed. Compressive, shear and tensile loading regimens with varying frequencies and stress amplitudes are imposed on both healthy cartilage and cartilage with experimental osteoarthritis. The in vivo measurement of articular cartilage deformation is essential to understand how mechanical forces distribute throughout the healthy tissue and change over time in the pathologic joint. We are investigating this question using a unique device allowing for evaluation of tissue-, matrix- and cellular-level mechanical properties in live tissue explants over extended periods of time. A motor-actuated phantom drove femoral and tibial bone segments through cyclic 3D motion patterns. However, it is not known how the sensitivity of cartilage to ameliorative and detrimental loading regimens is impacted by this disease. The purpose of this study was to determine the accuracy of knee kinematics and cartilage contact measured by volumetric dynamic MRI. Osteoarthritis is characterized by reduced matrix synthesis and increased matrix degradation, resulting in pain and loss of mobility. These load-induced changes are mediated in part by cellular deformations induced by tissue-level strains. While dynamic loading typically promotes biosynthetic activity and improves mechanical properties, immobilization and static loads inhibit anabolic activity and are detrimental to tissue function. The metabolic activity of articular cartilage and other connective tissues is regulated by mechanical loading. The delineation of surface changes is similar to 3-T MRI using cartilage-dedicated sequences. Real-time Visualization of the Effects of Cyclic and Static Loading on Healthy and Pathological Cartilage Mechanical and Structural Properties Phase-contrast imaging provides visualization of altered cartilage regions invisible in absorption CT with simultaneous high detail of the underlying bony abnormalities. UR Entrepreneurship & Translational Research. ![]()
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